is provided as a glycoprotein powder to be diluted with water, and acts in the body like LH, stimulating the testes to produce testosterone even when natural LH is not present or is deficient. It therefore is useful for maintaining testosterone production and/or testicle size during a steroid cycle. Use of this drug in the taper is rather counterproductive, since the resulting increased testosterone production is itself inhibitory to the hypothalamus and pituitary, delaying recovery. Thus, if this drug is used, it is preferably used during the cycle itself. A daily amount of 500 IU is generally sufficient, and in my opinion usage should not exceed 1000 IU per day.
Daily administration is superior to less frequent administration.
Doses over 1000 IU are noted for their tendency to cause or aggravate gynecomastia, and also act to desensitize the testicles to LH.
Pregnyl HCG may be injected intramuscularly, subcutaneously, or in a shallow injection about 1/4" deep with the needle going straight in. A 29 gauge insulin needle is recommended. Injection speed should be slow.
Pregnyl HCG, or Human chorionic gonadotropin, which is derived from the urine of pregnant women, is an injectable drug available commercially in the United States as well as many other countries. Pregnyl, made by Organon, and Profasi, made by Serono, are FDA approved for the treatment of undescended testicles in very young boys, hypogonadism (underproduction of testosterone) and as a fertility drug used to aid in inducing ovulation in women. Among athletes, Pregnyl HCG is used to stimulate natural testosterone production during or after a steroid cycle which has caused natural levels to be reduced. Stopping a steroid cycle abruptly, especially when endogenous androgens are absent, can cause a rapid loss in the athlete's newly acquired muscle. When HCG is used to stimulate natural production, a notably pronounced crash may be avoided. Pregnyl HCG is always packaged in 2 different vials,one with a powder and the other with a sterile solvent. These vials need to be mixed before injecting, and refrigerated should any be left for later use.
Average dose is 1 ampule per week at the end of the cycle.
/ Gonadotropin / HCG
Common uses and directions for Pregnyl
is an injectable, highly purified preparation of human chorionic gonadotropin obtained from the urine of pregnant women.
is used in the treatment of prepubertal cryptorchidism not due to anatomical obstruction. Pregnyl
is also used in selected cases of hypogonadotropic hypogonadism in males as well as for induction of ovulation and pregnancy in infertile women.
Human Chorionic Gonadotropin, HCG, is also widely used in athletics today. HCG is not a natural male hormone but mimics the natural hormone LH (Luetinising Hormone) almost identically. LH stimulates the production of testosterone by the testis in males. Thus HCG sends the same message which results in increased testosterone production by the testis due to the effect of HCG on the leydig cells of the testis. Athletes use Pregnyl HCG
to increase the body's own natural production of testosterone which is often depressed by long term steroid use.
Pregnyl, Gonadotropin additional information:
Human chorionic gonadotropin, Pregnyl HCG, is a polypeptide hormone produced by the human placenta. Pregnyl is a highly purified pyrogen-free preparation obtained from the urine of pregnant females.
Pregnyl, gonadotropin, mimics the action of the pituitary hormone luteinising hormone (LH) which controls the release of eggs from the ovary in women, and controls production of testosterone in men. Pregnyl is used to stimulate egg release in some infertile women after follicle development has been stimulated with follicle stimulating hormone. In men it is used in the management of delayed puberty, undescended testes and oligospermia (low sperm count).
Athletes use Pregnyl HCG to increase the body's own natural production of testosterone which is often depressed by long term steroid use.
should not be used by individuals with asthma, by boys who have not yet reached puberty or by individuals with decreased kidney function, epilepsy, heart failure or by individuals who are in the treatment of migraine.
There is no information available regarding the safety of Pregnyl
Possible side effects
may be associated with both minor as well as serious, life-threatening side effects and other potential risks. The following are some, but not all, of the potential side effects/concerns that you should discuss with your doctor before beginning treatment.
An injection of Pregnyl
can cause pain at the injection site, as well as headache, irritability, restlessness, depression, fatigue, and swelling due to retention of fluid.
A concern with fertility drugs is the risk of multiple pregnancies. About 80% of pregnancies, following fertility drug treatments with products like Pregnyl
result in single births. In instances of multiple pregnancies, the majority are twins. However, three or more babies may be conceived. Your physician should discuss the risk of multiple births with you before you begin your treatments.
Be sure to discuss with your doctor side effects and any other concerns associated with your treatment prior to beginning therapy.
For athletes it may be of interest that the prolonged use of Pregnyl HCG
could repress the body's own production of gonadotropins permanently, why short cycles are recommended.
Side effects from HCG use include gynecomastia, water retention, increased sex drive, mood alterations, headaches and high blood pressure.
raises androgen levels in males by up to 400% but it also raises estrogen levels dramatically which can cause a real case of gynecomastia if dosages get too elevated.
Another side effect seen from HCG use is morning sickness (nausea and vomiting).
There have been no cases of overdose complications with the use of Pregnyl HCG
nor have there been any associated carcinomas, liver or renal impairment.
in a tightly closed container and out of reach of children. Pregnyl
must be refrigerated after it is mixed together whereafter Pregnyl
has a life of about 10 weeks.
The above information is intended to supplement, not substitute for, the expertise and judgment of your physician, or other healthcare professional. It should not be construed to indicate that use of Pregnyl is safe, appropriate, or effective for you. Consult your healthcare professional before using Pregnyl.